Depression and Health Outcomes in Refractory Epilepsy

Phase 3 Completed 140 enrolled Columbia University National Institute of Neurological Disorders and Stroke (NINDS) · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

To define the benefits of antidepressant treatment or cognitive behavior therapy on mood, function, and quality of life in persons with depression and refractory epilepsy.

Timeline

Start: 2001-08
Primary completion: 2007-06
Completion: 2008-06

Publications

Maguire MJ, Marson AG, Nevitt SJ. Antidepressants for people with epilepsy and depression. Cochrane Database Syst Rev. 2021 Apr 16;4(4):CD010682. doi: 10.1002/14651858.CD010682.pub3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Sertraline	Small molecule	—	Oral

Depression and Health Outcomes in Refractory Epilepsy

Summary

Timeline

Publications

Drugs

Indications