Trazodone for Sleep Disturbance in Early Alcohol Recovery

Summary

This study is a randomized, double-blind clinical trial comparing trazodone (Desyrel) and placebo among sleep-disturbed, alcohol-dependent individuals shortly after discharge from an inpatient detoxification program. Subjects will undergo a baseline assessment and random assignment to trazodone or identical placebo for 12 weeks. All persons completing the alcohol detoxification at Stanley Street Treatment and Resources (SSTAR) will be screened. (SSTAR of Rhode Island provides detoxification services to non/underinsured persons of Rhode Island.)

Timeline

Start

2002-06

Primary completion

2006-01

Completion

2006-06

Outcome

Missed primary endpoint

paper The trazodone group experienced less improvement in the proportion of days abstinent during administration of study medication PMID 18616688 ↗

paper and an increase in the number of drinks per drinking day on cessation of the study medication PMID 18616688 ↗

Publications

• Results Friedmann PD, Rose JS, Swift R, Stout RL, Millman RP, Stein MD. Trazodone for sleep disturbance after alcohol detoxification: a double-blind, placebo-controlled trial. Alcohol Clin Exp Res. 2008 Sep;32(9):1652-60. doi: 10.1111/j.1530-0277.2008.00742.x. Epub 2008 Jul 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Trazodone	Small molecule	50 mg	—
Subject	Trazodone	Small molecule	150 mg	—

Indications