Androgen Replacement Therapy in Women With Hypopituitarism

Completed 50 enrolled Massachusetts General Hospital

RandomizedParallel-groupTreatment

Summary

This is a study to determine whether testosterone replacement with TheraDerm can improve bone density, mood, sex drive, thinking, and distribution of body fat and muscle mass in women with hypopituitarism.

Timeline

Start: 2001-09
Primary completion: —
Completion: 2004-12

Outcome

Met primary endpoint

paper NT-proBNP levels decreased in the transdermal testosterone group compared with placebo over three months. PMID 22137497 ↗

paper The difference between groups remained significant after controlling for baseline age, systolic blood pressure, body mass index, and homeostasis model assessment of insulin resistance. PMID 22137497 ↗

Publications

Lin E, McCabe E, Newton-Cheh C, Bloch K, Buys E, Wang T, Miller KK. Effects of transdermal testosterone on natriuretic peptide levels in women: a randomized placebo-controlled pilot study. Fertil Steril. 2012 Feb;97(2):489-93. doi: 10.1016/j.fertnstert.2011.11.001. Epub 2011 Dec 2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Testosterone	Small molecule	300 ug	Other