The Effect of Androgen and Growth Hormone on Height and Learning in Girls With Turner Syndrome

Phase 3 Completed 200 enrolled Thomas Jefferson University National Institute of Neurological Disorders and Stroke (NINDS) · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

The purposes of this study are to learn whether treatment with an androgen type hormone will improve the visual-spatial problems associated with Turner syndrome, and to evaluate the effect growth hormone, with and without androgen, has on growth.

Timeline

Start: 1992-11
Primary completion: 2007-01
Completion: 2012-06

Publications

Zeger MP, Shah K, Kowal K, Cutler GB Jr, Kushner H, Ross JL. Prospective study confirms oxandrolone-associated improvement in height in growth hormone-treated adolescent girls with Turner syndrome. Horm Res Paediatr. 2011;75(1):38-46. doi: 10.1159/000317529. Epub 2010 Aug 20.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Oxandrolone	Small molecule	0.06 mg/kg	Oral
Comparator	ethinyl estradiol	Small molecule	0.05 ug/kg	—

The Effect of Androgen and Growth Hormone on Height and Learning in Girls With Turner Syndrome

Summary

Timeline

Publications

Drugs

Indications