Dose-finding Study Using Pentostatin for Injection in the Treatment of Steroid-refractory aGvHD

Summary

To determine a safe and effective dose of pentostatin in steroid-refractory aGvHD and to identify the minimal effective dose of pentostatin defined as the lowest dose that produces a response in 20% or more of patients while producing treatment failure (defines as death, grade 3/4 toxicity, or progressive disease) in 40% or less of patients.

Timeline

Start

2002-01-30

Primary completion

2005-11-03

Completion

2005-11-03

Drugs

Indications