drugset / Trial / NCT00043719
Nitroglycerin Ointment for Preventing Bone Loss in Postmenopausal Women
Phase 3
Completed
200 enrolled
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
RandomizedParallel-groupDouble-blindPrevention
Summary
Osteopenia and osteoporosis cause thinning of bone tissue and loss of bone density over time. The purpose of this study is to determine the safety and effectiveness of nitroglycerin ointment for the treatment of osteopenia in postmenopausal women. Study hypothesis: On average, participants in the base therapy cohort who receive placebo ointment control and calcium/vitamin D will lose more bone density than participants in the nitroglycerin cohort over the 36-month period.
Timeline
- Start
- 2002-07
- Primary completion
- 2007-12
- Completion
- 2007-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Nitroglycerin | Unknown | — | Topical |
| Background | Calcium carbonate | Other / unclassified | — | — |
| Background | Vitamin D | Other / unclassified | — | — |