Minocycline to Treat Amyotrophic Lateral Sclerosis

Phase 3 Completed 400 enrolled National Institute of Neurological Disorders and Stroke (NINDS)

RandomizedDouble-blindTreatment

Summary

The purpose of this trial is to test the safety, tolerability, and effectiveness of minocycline compared to placebo in patients with amyotrophic lateral sclerosis (ALS).

Timeline

Start: 2003-01
Primary completion: —
Completion: 2007-01

Publications

Results Gordon PH, Moore DH, Miller RG, Florence JM, Verheijde JL, Doorish C, Hilton JF, Spitalny GM, MacArthur RB, Mitsumoto H, Neville HE, Boylan K, Mozaffar T, Belsh JM, Ravits J, Bedlack RS, Graves MC, McCluskey LF, Barohn RJ, Tandan R; Western ALS Study Group. Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial. Lancet Neurol. 2007 Dec;6(12):1045-53. doi: 10.1016/S1474-4422(07)70270-3. Epub 2007 Nov 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Minocycline	Small molecule	400 mg	Oral

Minocycline to Treat Amyotrophic Lateral Sclerosis

Summary

Timeline

Publications

Drugs

Indications