Gemcitabine Combined With Mistletoe in Treating Patients With Advanced Solid Tumors

Phase 1 Terminated 51 enrolled National Center for Complementary and Integrative Health (NCCIH) National Cancer Institute (NCI) · collab

Open-labelTreatment

Summary

RATIONALE: Drugs used in chemotherapy, such as gemcitabine, use different ways to stop tumor cells from dividing so they stop growing or die. Mistletoe may slow the growth of tumor cells and may be an effective treatment for solid tumors. PURPOSE: Phase I trial to study the effectiveness of combining gemcitabine with mistletoe in treating patients who have advanced solid tumors.

Timeline

Start: 2002-07
Primary completion: —
Completion: 2011-08

Publications

Results Mansky PJ, Wallerstedt DB, Sannes TS, Stagl J, Johnson LL, Blackman MR, Grem JL, Swain SM, Monahan BP. NCCAM/NCI Phase 1 Study of Mistletoe Extract and Gemcitabine in Patients with Advanced Solid Tumors. Evid Based Complement Alternat Med. 2013;2013:964592. doi: 10.1155/2013/964592. Epub 2013 Oct 27.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Gemcitabine	Small molecule	1300 mg/m2	Intravenous
Subject	Mistletoe extract	Unknown	250 mg	Subcutaneous

Gemcitabine Combined With Mistletoe in Treating Patients With Advanced Solid Tumors

Summary

Timeline

Publications

Drugs

Indications