Comparing Effects of 3 Sources of Garlic on Cholesterol Levels

Phase 2/3 Completed 220 enrolled National Center for Complementary and Integrative Health (NCCIH) Office of Dietary Supplements (ODS) · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of this study is to determine whether fresh garlic can positively affect cholesterol in adults with moderately high cholesterol levels. This study will also determine whether the same effects can be found for two main types of garlic supplements: a dried powdered garlic (designed to yield the same effect as fresh garlic) and an aged garlic extract preparation.

Timeline

Start: 2002-05
Primary completion: —
Completion: 2005-04

Outcome

Missed primary endpoint

paper There were no statistically significant effects of the 3 forms of garlic on LDL-C concentrations. PMID 17325296 ↗

Publications

Gardner CD, Lawson LD, Block E, Chatterjee LM, Kiazand A, Balise RR, Kraemer HC. Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial. Arch Intern Med. 2007 Feb 26;167(4):346-53. doi: 10.1001/archinte.167.4.346.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	aged garlic extract supplement	Traditional medicine (herbal / TCM)	4 g	Oral
Subject	powdered garlic supplement	Traditional medicine (herbal / TCM)	4 g	Oral
Subject	raw garlic	Unknown	4 g	Oral