drugset / Trial / NCT00078962

GTI-2040 and Gemcitabine in Treating Patients With Metastatic or Unresectable Solid Tumors

NCT00078962

Phase 1 Completed 40 enrolled National Cancer Institute (NCI)
NaSingle-groupOpen-labelTreatment

Summary

This phase I trial is studying the side effects and best dose of GTI-2040 and gemcitabine in treating patients with metastatic or unresectable solid tumors. Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. GTI-2040 may stop the growth of tumor cells by blocking the enzymes necessary for their growth and by making tumor cells more sensitive to gemcitabine

Timeline

Start
2004-01
Primary completion
2007-11
Completion

Drugs

EvaluationDrugModalityDoseRoute
Subject GTI-2040 Antisense oligonucleotide Intravenous
Subject Gemcitabine Small molecule Intravenous