Testosterone and Growth Hormone for Bone Loss in Men

Phase 2 Completed 35 enrolled University of Pennsylvania National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

Deficiency of testosterone, growth hormone, or both hormones can result in osteoporosis. If either hormone is replaced, the condition of the bones improves. The purpose of this study is to determine if dual hormone treatment for men deficient in testosterone and growth hormone improves bone structure more than testosterone treatment alone.

Timeline

Start: 2004-03
Primary completion: 2010-09
Completion: 2010-09

Publications

Results Al Mukaddam M, Rajapakse CS, Bhagat YA, Wehrli FW, Guo W, Peachey H, LeBeau SO, Zemel BS, Wang C, Swerdloff RS, Kapoor SC, Snyder PJ. Effects of testosterone and growth hormone on the structural and mechanical properties of bone by micro-MRI in the distal tibia of men with hypopituitarism. J Clin Endocrinol Metab. 2014 Apr;99(4):1236-44. doi: 10.1210/jc.2013-3665. Epub 2014 Jan 13.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Somatropin	Protein / enzyme biologic	2 ug/kg	Subcutaneous
Comparator	Testosterone	Small molecule	5 g	Other

Testosterone and Growth Hormone for Bone Loss in Men

Summary

Timeline

Publications

Drugs

Indications