drugset

drugset / Trial / NCT00082589

The Purpose of This Study is to Determine if Eplerenone is Effective in Treatment of Mild to Moderate Heart Failure

NCT00082589 ↗

Phase 4 Completed 250 enrolled Viatris Inc.

RandomizedSingle-groupDouble-blindTreatment

Summary

The purpose of this study is to determine if eplerenone is effective in the treatment of mild to moderate heart failure

Timeline

Start: 2004-04
Primary completion: —
Completion: 2006-03

Outcome

Missed primary endpoint

paper There was no apparent between-group difference in the changes in end-diastolic volume index PMID 20299607 ↗

paper had no detectable effect on parameters of LV remodeling. PMID 20299607 ↗

Publications

Udelson JE, Feldman AM, Greenberg B, Pitt B, Mukherjee R, Solomon HA, Konstam MA. Randomized, double-blind, multicenter, placebo-controlled study evaluating the effect of aldosterone antagonism with eplerenone on ventricular remodeling in patients with mild-to-moderate heart failure and left ventricular systolic dysfunction. Circ Heart Fail. 2010 May;3(3):347-53. doi: 10.1161/CIRCHEARTFAILURE.109.906909. Epub 2010 Mar 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Eplerenone	Unknown	50 mg	—

Indications