Irinotecan and Capecitabine in Treating Women With Advanced Breast Cancer

Phase 1 Completed 12 enrolled Roswell Park Cancer Institute

NaSingle-groupTreatment

Summary

RATIONALE: Drugs used in chemotherapy, such as irinotecan and capecitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Irinotecan may help capecitabine kill more tumor cells by making tumor cells more sensitive to the drug. PURPOSE: This phase I trial is studying the side effects and best dose of irinotecan and capecitabine in treating women with advanced breast cancer.

Timeline

Start: 2002-11
Primary completion: 2005-03
Completion: 2006-09

Publications

Results O'connor T, Rustum Y, Levine E, Creaven P. A phase I study of capecitabine and a modulatory dose of irinotecan in metastatic breast cancer. Cancer Chemother Pharmacol. 2008 Jan;61(1):125-31. doi: 10.1007/s00280-007-0456-1. Epub 2007 Apr 11.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Capecitabine	Small molecule	1500 mg/m2	Oral
Subject	Capecitabine	Small molecule	2000 mg/m2	Oral
Subject	Irinotecan	Small molecule	80 mg/m2	Intravenous

Irinotecan and Capecitabine in Treating Women With Advanced Breast Cancer

Summary

Timeline

Publications

Drugs

Indications