drugset / Trial / NCT00083590
Huperzine A in Alzheimer's Disease
Phase 2
Completed
150 enrolled
National Institute on Aging (NIA)
Alzheimer's Disease Cooperative Study (ADCS) · collabNeuro-Hitech · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
The present study will evaluate the safety and efficacy of the Chinese herb huperzine A in the treatment of Alzheimer's disease (AD) in a randomized controlled trial of its effect on cognitive function.
Timeline
- Start
- 2004-04
- Primary completion
- 2007-11
- Completion
- 2007-11
Publications
- Background Bai DL, Tang XC, He XC. Huperzine A, a potential therapeutic agent for treatment of Alzheimer's disease. Curr Med Chem. 2000 Mar;7(3):355-74. doi: 10.2174/0929867003375281.
- Background Ved HS, Koenig ML, Dave JR, Doctor BP. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. Neuroreport. 1997 Mar 3;8(4):963-8. doi: 10.1097/00001756-199703030-00029.
- Background Mazurek A: An open-label trial of huperzine A in the treatment of Alzheimer's disease. Alternative Therapies 5(2): 97-98, March 16, 2000.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Huperzine A | Traditional medicine (herbal / TCM) | 200 ug | — |
| Subject | Huperzine A | Traditional medicine (herbal / TCM) | 400 ug | — |