Boron Neutron Capture Therapy Using Boronophenylalanine-Fructose Complex in Treating Patients With Metastatic Melanoma

Phase 2 Terminated 4 enrolled European Organisation for Research and Treatment of Cancer - EORTC

Open-labelTreatment

Summary

RATIONALE: Boron neutron capture therapy using boronophenylalanine-fructose complex may kill tumor cells without harming normal tissue. PURPOSE: This phase II trial is studying how well boron neutron capture therapy using boronophenylalanine-fructose complex works in treating patients with metastatic melanoma.

Timeline

Start: 2004-04
Primary completion: 2006-10
Completion: —

Outcome

Outcome not reported

Stopped (Enrollment): “low accrual”

Publications

Background Wittig A, Moss RL, Stecher-Rasmussen F, Appelman K, Rassow J, Roca A, Sauerwein W. Neutron activation of patients following boron neutron capture therapy of brain tumors at the high flux reactor (HFR) Petten (EORTC Trials 11961 and 11011). Strahlenther Onkol. 2005 Dec;181(12):774-82. doi: 10.1007/s00066-005-1433-4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	boronophenylalanine-fructose complex	Unknown	—	Intravenous