drugset / Trial / NCT00085293

Decitabine in Treating Patients With Metastatic Papillary Thyroid Cancer or Follicular Thyroid Cancer Unresponsive to Iodine I 131

NCT00085293

Phase 2 Completed 12 enrolled National Cancer Institute (NCI)
NaSingle-groupOpen-labelTreatment

Summary

This phase II trial is studying how well decitabine works in treating patients with metastatic papillary thyroid cancer or follicular thyroid cancer that has stopped responding to radioactive iodine. Iodine I 131 (radioactive iodine) kills thyroid cancer cells. Metastatic thyroid cancer cells can lose the ability to be treated with radioactive iodine. Decitabine may help thyroid cancer cells regain the ability to respond to treatment with radioactive iodine.

Timeline

Start
2004-05
Primary completion
2014-01
Completion
2014-05

Drugs

EvaluationDrugModalityDoseRoute
Subject Decitabine Small molecule 6 mg/m2 Intravenous
Background rhTSH Protein / enzyme biologic