Maintaining Nonsmoking: Older Smokers - 1

NCT00086385 ↗

Phase 3 Completed 403 enrolled University of California, San Francisco National Institute on Drug Abuse (NIDA) · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study was to examine pharmacological and psychological interventions for smokers over 50.

Timeline

Start: 2001-09
Primary completion: 2009-03
Completion: 2009-03

Outcome

Met primary endpoint

paper The most clinically important findings were significant main effects for treatment condition, time and the treatment x time interaction. PMID 19392908 ↗

paper and was significantly more effective than E-NRT and ST across that period. PMID 19392908 ↗

Publications

Theodoulou A, Fanshawe TR, Leavens E, Theodoulou E, Wu AD, Heath L, Stewart C, Nollen N, Ahluwalia JS, Butler AR, Hajizadeh A, Thomas J, Lindson N, Hartmann-Boyce J. Differences in the effectiveness of individual-level smoking cessation interventions by socioeconomic status. Cochrane Database Syst Rev. 2025 Jan 27;1(1):CD015120. doi: 10.1002/14651858.CD015120.pub2.
Theodoulou A, Chepkin SC, Ye W, Fanshawe TR, Bullen C, Hartmann-Boyce J, Livingstone-Banks J, Hajizadeh A, Lindson N. Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev. 2023 Jun 19;6(6):CD013308. doi: 10.1002/14651858.CD013308.pub2.
Barnett PG, Wong W, Jeffers A, Munoz R, Humfleet G, Hall S. Cost-effectiveness of extended cessation treatment for older smokers. Addiction. 2014 Feb;109(2):314-22. doi: 10.1111/add.12404. Epub 2013 Dec 13.
Hall SM, Humfleet GL, Munoz RF, Reus VI, Robbins JA, Prochaska JJ. Extended treatment of older cigarette smokers. Addiction. 2009 Jun;104(6):1043-52. doi: 10.1111/j.1360-0443.2009.02548.x. Epub 2009 Apr 9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bupropion	Small molecule	—	—
Subject	Nicotine	Unknown	—	—