drugset / Trial / NCT00087191
EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer
NaSingle-groupOpen-labelDiagnostic
Summary
This clinical trial is studying the amount of EF5 and motexafin lutetium present in tumor cells and/or normal tissues of patients with abdominal (such as ovarian, colon, or stomach cancer) or non-small cell lung cancer. EF5 may be effective in measuring oxygen in tumor tissue. Photosensitizing drugs such as motexafin lutetium are absorbed by tumor cells and, when exposed to light, become active and kill the tumor cells. Knowing the level of oxygen in tumor tissue and the level of motexafin lutetium absorbed by tumors and normal tissue may help predict the effectiveness of anticancer therapy
Timeline
- Start
- 2004-05
- Primary completion
- 2006-01
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | EF5 | Diagnostic / imaging agent | — | Intravenous |
| Subject | motexafin lutetium | Small molecule | — | Intravenous |
Indications
appendix carcinoma
carcinoid tumor
exocrine pancreatic carcinoma
extrahepatic bile duct carcinoma
fallopian tube carcinoma
gallbladder cancer
gastric carcinoma
gastrointestinal stromal tumor
lung carcinoma in situ
non-small cell lung carcinoma
ovarian carcinoma
ovarian germ cell tumor
ovarian sarcoma
ovarian sex cord-stromal tumor
primary peritoneal carcinoma
rectal carcinoma
small intestine adenocarcinoma
small intestine leiomyosarcoma
small intestine lymphoma
uterine corpus sarcoma