Bone Loss in Women With Anorexia Nervosa

Phase 2/3 Completed 77 enrolled Massachusetts General Hospital National Center for Research Resources (NCRR) · collab National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collab

RandomizedFactorialQuadruple-blindTreatment

Summary

Women with Anorexia Nervosa have been found to have low bone density. The study will determine whether administration of low doses of a natural hormone, testosterone and/or risedronate, a medication to help prevent bone breakdown will improve or prevent bone loss in this condition.

Timeline

Start: 2003-06
Primary completion: 2008-04
Completion: 2008-04

Publications

Miller KK, Wexler TL, Zha AM, Lawson EA, Meenaghan EM, Misra M, Binstock AB, Herzog DB, Klibanski A. Androgen deficiency: association with increased anxiety and depression symptom severity in anorexia nervosa. J Clin Psychiatry. 2007 Jun;68(6):959-65. doi: 10.4088/jcp.v68n0621.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Risedronate	Small molecule	35 mg	Oral
Comparator	Testosterone	Small molecule	150 ug	Other

Bone Loss in Women With Anorexia Nervosa

Summary

Timeline

Publications

Drugs

Indications