Study of Darbepoetin Alfa for the Treatment of Anemia of Cancer

Summary

The purpose of this study is to evaluate the efficacy of darbepoetin alfa versus placebo in reducing the occurrences of red blood cell transfusions in subjects with anemia of cancer who are not receiving chemotherapy.

Timeline

Start

2004-04

Primary completion

2006-10

Completion

2006-12

Outcome

Missed primary endpoint

paper DA was not associated with a statistically significant reduction in transfusions. PMID 18227526 ↗

Publications

• Results Smith RE Jr, Aapro MS, Ludwig H, Pinter T, Smakal M, Ciuleanu TE, Chen L, Lillie T, Glaspy JA. Darbepoetin alpha for the treatment of anemia in patients with active cancer not receiving chemotherapy or radiotherapy: results of a phase III, multicenter, randomized, double-blind, placebo-controlled study. J Clin Oncol. 2008 Mar 1;26(7):1040-50. doi: 10.1200/JCO.2007.14.2885. Epub 2008 Jan 28.

Drugs

Indications