BRIEF-PCI: Brief Infusion of Eptifibatide Following Percutaneous Coronary Intervention

Summary

This trial was designed to examine the efficacy of a brief versus a standard prolonged (18 hours) infusion of eptifibatide in preventing troponin I release following successful coronary stenting.

Timeline

Start

2004-12

Primary completion

2007-07

Completion

2007-08

Outcome

Met primary endpoint

paper upper bound of 95% confidence interval: 7.8%; p < 0.012 for noninferiority PMID 19264239 ↗

paper It is not inferior to the standard 18-h infusion in preventing ischemic outcome PMID 19264239 ↗

Publications

• Results Saw J, Densem C, Walsh S, Jokhi P, Starovoytov A, Fox R, Wong G, Buller C, Ricci D, Mancini GB, Fung A. The effects of aspirin and clopidogrel response on myonecrosis after percutaneous coronary intervention: a BRIEF-PCI (Brief Infusion of Intravenous Eptifibatide Following Successful Percutaneous Coronary Intervention) trial substudy. JACC Cardiovasc Interv. 2008 Dec;1(6):654-9. doi: 10.1016/j.jcin.2008.08.017.
• Results Fung AY, Saw J, Starovoytov A, Densem C, Jokhi P, Walsh SJ, Fox RS, Humphries KH, Aymong E, Ricci DR, Webb JG, Hamburger JN, Carere RG, Buller CE. Abbreviated infusion of eptifibatide after successful coronary intervention The BRIEF-PCI (Brief Infusion of Eptifibatide Following Percutaneous Coronary Intervention) randomized trial. J Am Coll Cardiol. 2009 Mar 10;53(10):837-45. doi: 10.1016/j.jacc.2008.09.060.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Eptifibatide	Other / unclassified	—	Intravenous

Indications