drugset / Trial / NCT00114400
BVAIT: B-Vitamin Atherosclerosis Intervention Trial
RandomizedParallel-groupDouble-blindTreatment
Summary
The purpose of this study is to examine whether vitamin B supplementation will reduce the progression of early atherosclerosis in individuals over 40 years old and without clinical evidence of cardiovascular disease (CVD).
Timeline
- Start
- 2000-11
- Primary completion
- 2007-02
- Completion
- 2007-02
Publications
- Lin F, Pa J, Karim R, Hodis HN, Han SD, Henderson VW, St John JA, Mack WJ. Subclinical carotid artery atherosclerosis and cognitive function in older adults. Alzheimers Res Ther. 2022 May 7;14(1):63. doi: 10.1186/s13195-022-00997-7.
- Hodis HN, Mack WJ, Dustin L, Mahrer PR, Azen SP, Detrano R, Selhub J, Alaupovic P, Liu CR, Liu CH, Hwang J, Wilcox AG, Selzer RH; BVAIT Research Group. High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial. Stroke. 2009 Mar;40(3):730-6. doi: 10.1161/STROKEAHA.108.526798. Epub 2008 Dec 31.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Pyridoxine | Unknown | 50 mg | — |
| Subject | Vitamin B12 | Other / unclassified | 0.4 mg | — |
| Subject | folic acid | Other / unclassified | 5 mg | — |