Seroquel in Bipolar Depression Versus SSRI

Summary

The purpose of this study is to determine whether quetiapine is effective and safe in the acute treatment of bipolar depression and whether the effect is maintained when treatment is continued.

Timeline

Start

2005-05

Primary completion

—

Completion

2007-05

Outcome

Met primary endpoint

paper P < .001 for both quetiapine doses, P = .313 for paroxetine, vs placebo). PMID 20122366 ↗

paper Quetiapine (300 or 600 mg/d), but not paroxetine, was more effective than placebo for treating acute depressive episodes in bipolar I and II disorder. PMID 20122366 ↗

Publications

• McElroy SL, Weisler RH, Chang W, Olausson B, Paulsson B, Brecher M, Agambaram V, Merideth C, Nordenhem A, Young AH; EMBOLDEN II (Trial D1447C00134) Investigators. A double-blind, placebo-controlled study of quetiapine and paroxetine as monotherapy in adults with bipolar depression (EMBOLDEN II). J Clin Psychiatry. 2010 Feb;71(2):163-74. doi: 10.4088/JCP.08m04942gre. Epub 2010 Jan 26.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Paroxetine	Small molecule	20 mg	—
Subject	Quetiapine	Small molecule	300 mg	—
Subject	Quetiapine	Small molecule	600 mg	—

Indications