drugset / Trial / NCT00121823
Malaria Infection Diagnosed by Polymerase Chain Reaction (PCR) as a Means of Evaluating Pre-erythrocytic Candidate Malaria Vaccines
Phase 1/2
Completed
120 enrolled
London School of Hygiene and Tropical Medicine
Medical Research Council Unit, The Gambia · collabUniversity of Oxford · collabWellcome Trust · collab
RandomizedSingle-groupSingle-blindPrevention
Summary
The ability to test candidate pre-erythrocytic stage malaria vaccines, using a well-established sporozoite challenge model, in a field setting with group sizes of tens rather than hundreds of volunteers would greatly facilitate identification of the most promising vaccine candidates. The investigators assessed the suitability and acceptability of this method in a field trial in semi-immune volunteers exposed to natural infection during the high malaria transmission season.
Timeline
- Start
- 2004-06
- Primary completion
- —
- Completion
- 2004-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | FP9 ME-TRAP | Vaccine | 5e+07 unknown | Other |
| Subject | MVA ME-TRAP | Vaccine | 1e+08 unknown | Other |