IDEAL Study: Identification of the Determinants of the Efficacy of Arterial Blood Pressure Lowering Drugs

Summary

The principal scientific objective of the trial is to identify the factors that are associated with differential blood pressure responses between drugs. This may allow investigators to produce new hypotheses on the pathophysiology of hypertension and on the mechanisms of drug action. These factors can be of different types: * Environmental factors (sodium or alcohol intake); * Morphological (height, weight, body mass index, body surface area); * Initial blood pressure; * Electrocardiogram (ECG) parameters of left ventricular hypertrophy; * Biological parameters as the activity level of the renin angiotensin aldosterone system; * Genetic polymorphisms.

Timeline

Start

2004-10

Primary completion

2010-09

Completion

2010-09

Publications

• Results Gueyffier F, Subtil F, Bejan-Angoulvant T, Zerbib Y, Baguet JP, Boivin JM, Mercier A, Leftheriotis G, Gagnol JP, Fauvel JP, Giraud C, Bricca G, Maucort-Boulch D, Erpeldinger S; IDEAL Trial Group. Can we identify response markers to antihypertensive drugs? First results from the IDEAL Trial. J Hum Hypertens. 2015 Jan;29(1):22-7. doi: 10.1038/jhh.2014.29. Epub 2014 Apr 17.

Drugs

Indications