Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain

Phase 1/2 Completed 40 enrolled Yale University National Institute on Alcohol Abuse and Alcoholism (NIAAA) · collab

Non-randomizedParallel-groupOpen-labelTreatment

Summary

This study will test a combination of the drugs naltrexone and bupropion with weight-concerned smokers to investigate whether or not this combination of drugs improves smoking cessation quit rates and minimizes post quit weight gain.

Timeline

Start: 2004-12
Primary completion: —
Completion: 2005-12

Outcome

Missed primary endpoint

paper nor were there differences in either continuous or point prevalence abstinence from smoking. PMID 17587504 ↗

paper mean=1.67 lb) than those in the bupropion only group (mean=3.17 lb; p=.35; Cohen's d=0.56). PMID 17587504 ↗

Publications

Results Toll BA, Leary V, Wu R, Salovey P, Meandzija B, O'Malley SS. A preliminary investigation of naltrexone augmentation of bupropion to stop smoking with less weight gain. Addict Behav. 2008 Jan;33(1):173-9. doi: 10.1016/j.addbeh.2007.05.012. Epub 2007 Jun 2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bupropion	Small molecule	300 mg	—
Subject	Naltrexone	Small molecule	25 mg	—