Prophylactic Antibiotic Treatment of Patients With Chronic Obstructive Lung Disease (COLD)

Summary

The purpose of the study is to investigate, in patients with moderate to severe chronic obstructive lung disease, whether intermittent antibiotic treatment leads to: * A slower rate of decline in forced expiratory volume in one second (FEV1); * A reduction in the frequency and severity of exacerbations; * Fewer hospital admissions for chronic obstructive pulmonary disease (COPD); * Lower mortality; * An improved quality of life as compared to a group of placebo treated patients.

Timeline

Start

2001-05

Primary completion

—

Completion

2007-12

Publications

• Sorensen AK, Holmgaard DB, Mygind LH, Johansen J, Pedersen C. Neutrophil-to-lymphocyte ratio, calprotectin and YKL-40 in patients with chronic obstructive pulmonary disease: correlations and 5-year mortality - a cohort study. J Inflamm (Lond). 2015 Mar 18;12:20. doi: 10.1186/s12950-015-0064-5. eCollection 2015.
• Holmgaard DB, Mygind LH, Titlestad IL, Madsen H, Pedersen SS, Johansen JS, Pedersen C. Plasma YKL-40 and all-cause mortality in patients with chronic obstructive pulmonary disease. BMC Pulm Med. 2013 Dec 30;13:77. doi: 10.1186/1471-2466-13-77.

Drugs

Indications