Civilian Post-Traumatic Stress Disorder Risperidone Clinical Trial

Phase 1/2 Completed 65 enrolled Emory University Janssen, LP · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of this study is to determine whether the administration of risperidone is effective in the treatment of selective serotonin reuptake inhibitor (SSRI)-resistant post-traumatic stress disorder (PTSD) in civilians.

Timeline

Start: 2004-04
Primary completion: 2006-09
Completion: 2006-09

Outcome

Missed primary endpoint

paper For all patients across all phases, PTSD and related symptoms improved with no significant differences between groups. PMID 18278987 ↗

Publications

Rothbaum BO, Killeen TK, Davidson JR, Brady KT, Connor KM, Heekin MH. Placebo-controlled trial of risperidone augmentation for selective serotonin reuptake inhibitor-resistant civilian posttraumatic stress disorder. J Clin Psychiatry. 2008 Apr;69(4):520-5. doi: 10.4088/jcp.v69n0402.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Risperidone	Other / unclassified	—	—
Subject	Sertraline	Small molecule	—	—