Methylphenidate Treatment for Cocaine Abuse and ADHD - 1

Phase 1 Completed 124 enrolled New York State Psychiatric Institute National Institute on Drug Abuse (NIDA) · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

Many cocaine dependent individuals are also diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). Methylphenidate (Ritalin) is currently approved to treat individuals diagnosed with ADHD. The purpose of this study is to determine the effectiveness of methylphenidate in treating ADHD symptoms in cocaine dependent individuals.

Timeline

Start: 1998-04
Primary completion: 2004-03
Completion: 2004-03

Outcome

Missed primary endpoint

paper Although sustained-release MPH did not show superiority over PBO in treating ADHD symptoms PMID 16930863 ↗

Publications

Results Levin FR, Evans SM, Brooks DJ, Garawi F. Treatment of cocaine dependent treatment seekers with adult ADHD: double-blind comparison of methylphenidate and placebo. Drug Alcohol Depend. 2007 Feb 23;87(1):20-9. doi: 10.1016/j.drugalcdep.2006.07.004. Epub 2006 Aug 22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Methylphenidate	Small molecule	40 mg	—
Subject	Methylphenidate	Small molecule	60 mg	—