Lowering Total Immunosuppressive Load in Renal Transplant Recipients More Than 12 Months Posttransplant

Phase 4 Terminated 298 enrolled University of Oslo School of Pharmacy

RandomizedParallel-groupOpen-labelPrevention

Summary

To compare the change in renal function between CsA or MMF withdrawal from before to 12 months after drug withdrawal in renal transplant recipients on triple immunosuppressive therapy

Timeline

Start: 2003-02
Primary completion: 2005-11
Completion: 2007-02

Outcome

Outcome not reported

Stopped: “To high rejection rate in CsA withdrawal arm”

Publications

Asberg A, Apeland T, Reisaeter AV, Foss A, Leivestad T, Heldal K, Thorud LO, Eriksen BO, Hartmann A; NILS Study Group. Long-term outcomes after cyclosporine or mycophenolate withdrawal in kidney transplantation - results from an aborted trial. Clin Transplant. 2013 Mar-Apr;27(2):E151-6. doi: 10.1111/ctr.12076. Epub 2013 Jan 27.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cyclosporine	Peptide	—	—
Subject	Mycophenolate Mofetil	Small molecule	2 g	—

Indications

No indication recorded.