drugset / Trial / NCT00164424
Episodic Acyclovir Therapy for Genital Ulcers
Phase 2/3
Completed
613 enrolled
Centers for Disease Control and Prevention
London School of Hygiene and Tropical Medicine · collabNational Institute for Communicable Diseases, South Africa · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
The purpose of this study is to determine if acyclovir episodic treatment has an effect in ulcer healing and if it should be added to the syndromic management of genital ulcer disease.
Timeline
- Start
- 2005-03
- Primary completion
- 2009-03
- Completion
- 2011-07
Publications
- Paz Bailey G, Sternberg M, Lewis DA, Puren A. Acute HIV infections among men with genital ulcer disease in South Africa. J Infect Dis. 2010 Jun 15;201(12):1811-5. doi: 10.1086/652785.
- Paz-Bailey G, Sternberg M, Puren AJ, Markowitz LE, Ballard R, Delany S, Hawkes S, Nwanyanwu O, Ryan C, Lewis DA. Improvement in healing and reduction in HIV shedding with episodic acyclovir therapy as part of syndromic management among men: a randomized, controlled trial. J Infect Dis. 2009 Oct 1;200(7):1039-49. doi: 10.1086/605647.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Acyclovir | Small molecule | 400 mg | — |