drugset / Trial / NCT00166166
Endothelial Hyperpolarization in Humans
Phase 2
Terminated
174 enrolled
Emory University
National Heart, Lung, and Blood Institute (NHLBI) · collab
Non-randomizedSingle-groupOpen-labelDiagnostic
Summary
The purpose of this study is to elucidate the role Endothelium-Derived Hyperpolarizing Factor (EDHF) plays in dilating blood vessels and whether it differs between healthy people and those with high cholesterol. A second purpose of the study is to determine the identity of EDHF.
Timeline
- Start
- 2002-07
- Primary completion
- 2013-01
- Completion
- 2013-01
Publications
- Results Ozkor MA, Murrow JR, Rahman AM, Kavtaradze N, Lin J, Manatunga A, Quyyumi AA. Endothelium-derived hyperpolarizing factor determines resting and stimulated forearm vasodilator tone in health and in disease. Circulation. 2011 May 24;123(20):2244-53. doi: 10.1161/CIRCULATIONAHA.110.990317. Epub 2011 May 9.
- Ozkor MA, Hayek SS, Rahman AM, Murrow JR, Kavtaradze N, Lin J, Manatunga A, Quyyumi AA. Contribution of endothelium-derived hyperpolarizing factor to exercise-induced vasodilation in health and hypercholesterolemia. Vasc Med. 2015 Feb;20(1):14-22. doi: 10.1177/1358863X14565374. Epub 2015 Feb 3.
- Rahman AM, Murrow JR, Ozkor MA, Kavtaradze N, Lin J, De Staercke C, Hooper WC, Manatunga A, Hayek S, Quyyumi AA. Endothelium-derived hyperpolarizing factor mediates bradykinin-stimulated tissue plasminogen activator release in humans. J Vasc Res. 2014;51(3):200-8. doi: 10.1159/000362666. Epub 2014 Jun 4.
- Ozkor MA, Rahman AM, Murrow JR, Kavtaradze N, Lin J, Manatunga A, Hayek S, Quyyumi AA. Differences in vascular nitric oxide and endothelium-derived hyperpolarizing factor bioavailability in blacks and whites. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1320-7. doi: 10.1161/ATVBAHA.113.303136. Epub 2014 Mar 27.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Acetylcholine | Small molecule | 7.5 ug | Other |
| Subject | Acetylcholine | Small molecule | 15 ug | Other |
| Subject | Acetylcholine | Small molecule | 30 ug | Other |
| Subject | Bradykinin | Protein / enzyme biologic | 100 ng | Other |
| Subject | Bradykinin | Protein / enzyme biologic | 200 ng | Other |
| Subject | Bradykinin | Protein / enzyme biologic | 400 ng | Other |
| Subject | Fluconazole | Small molecule | 0.4 unknown | Other |
| Subject | L-NMMA | Unknown | 0.008 mmol | Other |
| Subject | Sodium Nitroprusside | Unknown | 1.6 mg | Other |
| Subject | Sodium Nitroprusside | Unknown | 3.2 mg | Other |
| Subject | Tetraethylammonium | Unknown | 1 mg | Other |