drugset / Trial / NCT00183391
Stimulant Versus Nonstimulant Medication for Attention Deficit Hyperactivity Disorder in Children
Phase 4
Completed
232 enrolled
Icahn School of Medicine at Mount Sinai
National Institute of Mental Health (NIMH) · collab
RandomizedCrossoverDouble-blindTreatment
Summary
This study will determine the effectiveness of stimulant and nonstimulant medication in treating the symptoms of attention deficit hyperactivity disorder (ADHD) in children and adolescents.
Timeline
- Start
- 2005-07
- Primary completion
- 2011-06
- Completion
- 2011-06
Publications
- Results Bedard AC, Stein MA, Halperin JM, Krone B, Rajwan E, Newcorn JH. Differential impact of methylphenidate and atomoxetine on sustained attention in youth with attention-deficit/hyperactivity disorder. J Child Psychol Psychiatry. 2015 Jan;56(1):40-8. doi: 10.1111/jcpp.12272. Epub 2014 Jun 19.
- Schulz KP, Bedard AV, Fan J, Hildebrandt TB, Stein MA, Ivanov I, Halperin JM, Newcorn JH. Striatal Activation Predicts Differential Therapeutic Responses to Methylphenidate and Atomoxetine. J Am Acad Child Adolesc Psychiatry. 2017 Jul;56(7):602-609.e2. doi: 10.1016/j.jaac.2017.04.005. Epub 2017 May 10.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Atomoxetine | Other / unclassified | 1.4 mg/kg | — |
| Comparator | Methylphenidate | Small molecule | 52.4 mg | — |