Memantine Treatment for Improving Rehabilitation Outcomes and Preventing Depression in Older Adults

Phase 4 Completed 35 enrolled Eric Lenze National Institute of Mental Health (NIMH) · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

This study will evaluate the effectiveness of memantine in improving rehabilitation outcomes and preventing major depressive disorder in older adults who have been admitted to a rehabilitation hospital for a hip fracture or cardiopulmonary condition.

Timeline

Start: 2005-08
Primary completion: 2009-06
Completion: 2009-06

Outcome

Missed primary endpoint

registry analysis (superiority test); Memantine (1) vs Placebo (2); p = 0.42; Mean Difference (Final Values) 2; Mixed Models Analysis NCT00183729 ↗

paper However, there were no group differences between the memantine-randomized and placebo randomized participants on any outcome. PMID 22173933 ↗

Publications

Results Lenze EJ, Skidmore ER, Begley AE, Newcomer JW, Butters MA, Whyte EM. Memantine for late-life depression and apathy after a disabling medical event: a 12-week, double-blind placebo-controlled pilot study. Int J Geriatr Psychiatry. 2012 Sep;27(9):974-80. doi: 10.1002/gps.2813. Epub 2011 Dec 16.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Memantine	Unknown	10 mg	—