Prophylactic Treatment of Episodic Cluster Headache

Summary

The purpose of this study is to determine whether candesartan cilexetil are effective prophylactic treatment of episodic Cluster headache

Timeline

Start

2005-03

Primary completion

2009-06

Completion

2009-12

Outcome

Missed primary endpoint

paper The difference between the candesartan and placebo group was not significant with the pre-planned non-parametric ranking test PMID 23598371 ↗

Publications

• Background Tronvik E, Stovner LJ, Helde G, Sand T, Bovim G. Prophylactic treatment of migraine with an angiotensin II receptor blocker: a randomized controlled trial. JAMA. 2003 Jan 1;289(1):65-9. doi: 10.1001/jama.289.1.65.
• Results Tronvik E, Wienecke T, Monstad I, Dahlof C, Boe MG, Tjensvoll AB, Salvesen R, Zwart JA, Jansson SO, Stovner LJ. Randomised trial on episodic cluster headache with an angiotensin II receptor blocker. Cephalalgia. 2013 Sep;33(12):1026-34. doi: 10.1177/0333102413484989. Epub 2013 Apr 18.

Drugs

Indications