Blockade of Vascular Potassium Channels During Human Endotoxemia

Phase 1 Completed 36 enrolled Radboud University Medical Center ZonMw: The Netherlands Organisation for Health Research and Development · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.

Timeline

Start: 2003-01
Primary completion: 2005-06
Completion: 2005-06

Publications

Results Pickkers P, Dorresteijn MJ, Bouw MP, van der Hoeven JG, Smits P. In vivo evidence for nitric oxide-mediated calcium-activated potassium-channel activation during human endotoxemia. Circulation. 2006 Aug 1;114(5):414-21. doi: 10.1161/CIRCULATIONAHA.105.590232. Epub 2006 Jul 24.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	L-NMMA	Unknown	0.2 unknown	Other
Subject	Quinin	Unknown	—	—
Subject	Tetraethylammonium	Unknown	—	Other
Subject	Tolbutamide	Small molecule	—	—

Indications

No indication recorded.