Effect of Age on the Renal Clearance of Adefovir

Phase 4 Withdrawn University of California, San Francisco

Non-randomizedParallel-groupOpen-label

Summary

Healthy African American subjects with normal hepatic and renal function will be administered 10mg adefovir dipivoxil in a fasting state. Subjects will have blood and urine collections over the following 24 hours for the measurement of adefovir renal clearance. To investigate the role of age in renal adefovir elimination, 8 subjects will be enrolled from each of the following age groups: 18-25 years and 48-55 years.

Timeline

Start: 2005-08
Primary completion: 2008-04
Completion: 2008-04

Publications

Background Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin ET, Brett CM, Burchard EG, Ferrin TE, Huang CC, Leabman MK, Giacomini KM. Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenet Genomics. 2005 Apr;15(4):201-9. doi: 10.1097/01213011-200504000-00003.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Adefovir dipivoxil	Small molecule	10 mg	Oral

Indications

No indication recorded.