Olanzapine Plus Carbamazepine in the Treatment of Bipolar I Mania

Summary

This trial will assess any efficacious benefit and any safety issues associated with the concomitant use of olanzapine and carbamazepine for the treatment of patients with bipolar I disorder, manic or mixed episodes

Timeline

Start

2004-09

Primary completion

—

Completion

2006-06

Outcome

Missed primary endpoint

paper The combination of olanzapine and carbamazepine did not have superior efficacy to carbamazepine alone. PMID 18245032 ↗

Publications

• Tohen M, Bowden CL, Smulevich AB, Bergstrom R, Quinlan T, Osuntokun O, Wang WV, Oliff HS, Martenyi F, Kryzhanovskaya LA, Greil W. Olanzapine plus carbamazepine v. carbamazepine alone in treating manic episodes. Br J Psychiatry. 2008 Feb;192(2):135-43. doi: 10.1192/bjp.bp.107.041301.

Drugs

Indications