Dendritic Cell Based Therapy of Metastatic Breast Cancer

NCT00197925 ↗

Phase 1/2 Terminated 40 enrolled Herlev Hospital

Non-randomizedSingle-groupOpen-labelTreatment

Summary

The study aim to show if vaccination with autologous dendritic cells pulsed with onco-peptides in combination with adjuvant cytokine can induce a measurable immune response in patients with metastatic breast cancer, and to evaluate the clinical effect (objective response rate) of the vaccination regime.

Timeline

Start: 2004-09
Primary completion: —
Completion: —

Outcome

Outcome not reported

Stopped (Enrollment): “all patients recruited”

Publications

Background Svane IM, Pedersen AE, Johnsen HE, Nielsen D, Kamby C, Gaarsdal E, Nikolajsen K, Buus S, Claesson MH. Vaccination with p53-peptide-pulsed dendritic cells, of patients with advanced breast cancer: report from a phase I study. Cancer Immunol Immunother. 2004 Jul;53(7):633-41. doi: 10.1007/s00262-003-0493-5. Epub 2004 Feb 25.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Onco-peptide loaded autologous dendritic cells	Cell therapy	5e+06 cells	Other