Phase II Trial of Pentostatin in Steroid Refractory Acute Graft Versus Host Disease

Summary

This study will evaluate the response rate to treatment with pentostatin in steroid-refractory acute graft versus host disease.

Timeline

Start

2003-07

Primary completion

2007-10

Completion

2013-07

Publications

• Results Poi MJ, Hofmeister CC, Johnston JS, Edwards RB, Jansak BS, Lucas DM, Farag SS, Dalton JT, Devine SM, Grever MR, Phelps MA. Standard pentostatin dose reductions in renal insufficiency are not adequate: selected patients with steroid-refractory acute graft-versus-host disease. Clin Pharmacokinet. 2013 Aug;52(8):705-12. doi: 10.1007/s40262-013-0064-7.

Drugs

Indications