Effects of Anemia Correction on Vascular and Monocyte Function in Renal Transplant Recipients

Summary

Correction of anaemia in renal transplant recipients by parenteral application of recombinant erythropoietin and if necessary iron will improve large artery function (endothelial function and elasticity), as assessed by ultrasound techniques and applanation tonometry. The changes in large artery function will be reflected by changes in serological markers of endothelial function and oxidative stress and by changes in monocyte function and apoptosis. There are gender differences in the responses of vascular function to correction of anemia. Besides improvement of large artery function, correction of anemia will also affect parameters of graft function, i.e. glomerular and tubular proteinuria.

Timeline

Start

2005-06

Primary completion

2010-01

Completion

2010-01

Drugs

Indications