Seroquel Therapy for Substance Use Disorders Comorbid With Schizophrenia

Summary

It is hypothesized that the atypical antipsychotic, Seroquel, will cause significant reduction in drug and alcohol cravings in patients with schizophrenia and comorbid cocaine and/methamphetamine dependence compared to the atypical antipsychotic, risperidone (Risperdal). Patients treated with Seroquel will have less use of cocaine and/or methamphetamine as measured by the Time Line Follow-back, over a 24-week follow-up period.

Timeline

Start

2003-11

Primary completion

—

Completion

2005-12

Drugs

Indications