Does Fluoxetine Have an Effect on the CNS CRF Systems in Women Abused in Childhood?

Summary

The primary objective of this project is to determine whether treatment with the SSRI, fluoxetine versus placebo reverses alterations in the central CRF system induced by early life stress experiences (i.e. childhood sexual and/or physical abuse) in cases with and without major depression. We also evaluate whether neuroendocrine changes after SSRI treatment correlate with clinical improvement.

Timeline

Start

1997-12

Primary completion

2007-11

Completion

2007-11

Drugs

Indications