Docetaxel Combined With Ketoconazole in Treatment of Breast Cancer

NCT00212095 ↗

Phase 2 Completed 30 enrolled National University Hospital, Singapore

Non-randomizedSingle-groupOpen-labelTreatment

Summary

Patients with locally advanced or metastatic breast cancer and with measurable primary breast tumor will be treated with 70mg docetaxel combined with ketoconazole. Serial tumor biopsies and plasma samples will be taken for gene expression and proteomics studies to identify biomarkers that may predict for treatment response.

Timeline

Start: 2005-06
Primary completion: 2007-04
Completion: 2012-06

Publications

Lim YW, Goh BC, Wang LZ, Tan SH, Chuah BYS, Lim SE, Iau P, Buhari SA, Chan CW, Sukri NB, Cordero MT, Soo R, Lee SC. Pharmacokinetics and pharmacodynamics of docetaxel with or without ketoconazole modulation in chemonaive breast cancer patients. Ann Oncol. 2010 Nov;21(11):2175-2182. doi: 10.1093/annonc/mdq230. Epub 2010 Apr 29.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Docetaxel	Small molecule	70 mg	—
Background	Ketoconazole	Small molecule	200 mg	Oral

Docetaxel Combined With Ketoconazole in Treatment of Breast Cancer

Summary

Timeline

Publications

Drugs

Indications