Combination Vaccination Before HIV Treatment Interruption

Phase 1/2 Completed 52 enrolled Ottawa Hospital Research Institute CIHR Canadian HIV Trials Network · collab Canadian Institutes of Health Research (CIHR) · collab Ontario HIV Treatment Network · collab

RandomizedSingle-groupTriple-blindTreatment

Summary

The purpose of this study is to determine if vaccination before a structured treatment interruption (STI) is associated with an improvement in immune function, resulting in a delayed and reduced rebound in the amount of HIV virus in the blood.

Timeline

Start: 2004-04
Primary completion: 2010-07
Completion: 2010-11

Publications

Angel JB, Routy JP, Tremblay C, Ayers D, Woods R, Singer J, Bernard N, Kovacs C, Smaill F, Gurunathan S, Sekaly RP. A randomized controlled trial of HIV therapeutic vaccination using ALVAC with or without Remune. AIDS. 2011 Mar 27;25(6):731-9. doi: 10.1097/QAD.0b013e328344cea5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	ALVAC	Vaccine	1 ml	Intramuscular
Subject	Remune	Vaccine	1 ml	Intramuscular

Combination Vaccination Before HIV Treatment Interruption

Summary

Timeline

Publications

Drugs

Indications