Effects of Hormonal Contraceptives on Liver Proteins and Coagulation Factors: A Comparison of a Contraceptive Vaginal Ring and an Oral Contraceptive

Phase 2 Completed 50 enrolled Population Council United States Agency for International Development (USAID) · collab

RandomizedParallel-groupDouble-blindPrevention

Summary

The purpose of this 3-month (cycle) study was to evaluate the effects of hormonal contraceptives containing a progestin and an estrogen on liver proteins and coagulation factors that are sensitive to estrogen. In this study, a contraceptive vaginal ring containing Nestorone® (a progestin with no androgenic properties) and ethinyl estradiol was compared to an oral contraceptive containing levonorgestrel (an androgenic progestin) and ethinyl estradiol.

Timeline

Start: 2003-03
Primary completion: —
Completion: 2004-02

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Levonorgestrel	Small molecule	150 ug	Oral
Subject	Segesterone Acetate	Small molecule	150 ug	Other
Subject	ethinyl estradiol	Small molecule	15 ug	Other
Subject	ethinyl estradiol	Small molecule	30 ug	Other

Indications

No indication recorded.