L-arginine Supplementation and Exercise; L-arginine Supplementation and Renal Function

Phase 4 Completed 30 enrolled University Hospital, Strasbourg, France

RandomizedParallel-groupDouble-blindTreatment

Summary

* exercise capacities are still altered after heart transplantation partly due to peripheral endothelial dysfunction * cyclosporin-induced renal dysfunction may be due to renal endothelial dysfunction and can be reversed in an animal model by L-arginine supplementation * to determine the potential beneficial effect of L-arginine supplementation on exercise capacity and renal function of heart transplant recipients

Timeline

Start: 2004-02
Primary completion: —
Completion: 2004-12

Publications

Results Doutreleau S, Rouyer O, Di Marco P, Lonsdorfer E, Richard R, Piquard F, Geny B. L-arginine supplementation improves exercise capacity after a heart transplant. Am J Clin Nutr. 2010 May;91(5):1261-7. doi: 10.3945/ajcn.2009.27881. Epub 2010 Mar 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	L-arginine	Small molecule	12 g	Oral

Indications

No indication recorded.