Aldosterone and Vascular Disease in Diabetes Mellitus

Completed 46 enrolled Brigham and Women's Hospital National Institutes of Health (NIH) · collab

RandomizedCrossoverDouble-blindTreatment

Summary

Specific aims for this proposal are to determine in patients with diabetes mellitus the effects of an aldosterone receptor antagonist on: 1. Coronary microvascular function assessed by MRI perfusion reserve, 2. Endothelial dysfunction assessed by brachial artery reactivity studies, and 3. Inflammation assessed by blood measurements of c-reactive protein (CRP), monocyte chemoattractant protein-1 (MCP-1), and plasminogen activator inhibitor-1 (PAI-1).

Timeline

Start: 2003-08
Primary completion: 2006-03
Completion: 2006-03

Outcome

Met primary endpoint

paper myocardial perfusion reserve was significantly higher after eplerenone than after hydrochlorothiazide (median 1.57 vs. 1.30; P = 0.03). PMID 17488800 ↗

Publications

Results Joffe HV, Kwong RY, Gerhard-Herman MD, Rice C, Feldman K, Adler GK. Beneficial effects of eplerenone versus hydrochlorothiazide on coronary circulatory function in patients with diabetes mellitus. J Clin Endocrinol Metab. 2007 Jul;92(7):2552-8. doi: 10.1210/jc.2007-0393. Epub 2007 May 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Eplerenone	Unknown	50 mg	—
Comparator	Hydrochlorothiazide	Unknown	12.5 mg	—