Effect of Paroxetine on Smokers' Cardiovascular Response to Stress - 1

Summary

Smokers report that they often smoke cigarettes during stressful times. The combined effect of smoking and exposure to stress leads to exaggerated increases in blood pressure, heart rate and other measures of stress response. This combination may result in greater cardiovascular harm than either smoking or stress alone. The purpose of this study is to determine the effects of paroxetine on the response to stress after smoking.

Timeline

Start

2005-10

Primary completion

2010-08

Completion

2010-08

Outcome

Met primary endpoint

registry MEAN After 4 Weeks of Placebo: 16.85 (Standard Error 0.78) mmHg MEAN After 4 Weeks of Paroxetine: 11.71 (Standard Error 0.78) mmHg NCT00218439 ↗

registry analysis (unspecified test); After 4 Weeks of Placebo vs After 4 Weeks of Paroxetine; p <0.001; Mixed Models Analysis NCT00218439 ↗

Publications

• Kotlyar M, al'Absi M, Thuras P, Vuchetich JP, Adson DE, Nowack AL, Hatsukami DK. Effect of paroxetine on physiological response to stress and smoking. Psychosom Med. 2013 Apr;75(3):236-43. doi: 10.1097/PSY.0b013e3182898f6d. Epub 2013 Mar 15.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Paroxetine	Small molecule	20 mg	—

Indications