Double-Blind, Parallel, Randomised Study to Investigate the Effect of Oral Probiotics in Infants With Atopic Dermatitis

Completed 45 enrolled Groningen Research Institute for Asthma and COPD Numico Research Wageningen, the Netherlands · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

To study the effect of supplementation of a hydrolyzed formula with probiotic bacteria on clinical and immunological parameters in infants with AD with and without CMA and to compare effectiveness of different strains of probiotics.

Timeline

Start: 2001-03
Primary completion: —
Completion: 2002-09

Outcome

Missed primary endpoint

paper No statistically significant effects of probiotic supplementation on SCORAD, sensitization, inflammatory parameters or cytokine production between groups were found. PMID 16839405 ↗

Publications

Results Brouwer ML, Wolt-Plompen SA, Dubois AE, van der Heide S, Jansen DF, Hoijer MA, Kauffman HF, Duiverman EJ. No effects of probiotics on atopic dermatitis in infancy: a randomized placebo-controlled trial. Clin Exp Allergy. 2006 Jul;36(7):899-906. doi: 10.1111/j.1365-2222.2006.02513.x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lactobacillus GG	Other / unclassified	—	Oral
Subject	Lactobacillus rhamnosus	Other / unclassified	—	Oral